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Jake J Thiessen Selected Research

valspodar (PSC 833)

3/2006PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.
3/2004Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats.
12/2003Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.
8/2003Source of a micro-nutrient in a semi-synthetic basal diet as a causative factor in inducing urinary calculi in rats and its inhibition by PSC 833, a potent inhibitor of P-glycoprotein.

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Jake J Thiessen Research Topics

Disease

3Iron Overload
04/2010 - 06/2007
3Carcinogenesis
03/2006 - 12/2003
3Neoplasms (Cancer)
03/2006 - 08/2003
2Liver Neoplasms (Liver Cancer)
03/2004 - 12/2003
1Hemochromatosis (Bronze Diabetes)
06/2007
1Thrombosis (Thrombus)
06/2005
1Hypotension (Low Blood Pressure)
04/2004
1Anorexia
04/2004
1Nausea
04/2004
1Lethargy
04/2004
1Heart Failure
03/2004
1Breast Neoplasms (Breast Cancer)
03/2004
1Urinary Calculi (Urinary Calculus)
08/2003

Drug/Important Bio-Agent (IBA)

4valspodar (PSC 833)IBA
03/2006 - 08/2003
4Member 1 Subfamily B ATP Binding Cassette TransporterIBA
03/2006 - 08/2003
3Chelating AgentsIBA
04/2010 - 06/2007
3IronIBA
04/2010 - 06/2007
2DeferiproneIBA
06/2007 - 06/2007
1Iron Chelating AgentsIBA
04/2010
1Aligeron (AS 2)IBA
03/2006
11,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA
03/2006
1Factor XIIIaIBA
06/2005
1BilirubinIBA
04/2004
1CreatinineIBA
04/2004
1Transaminases (Aminotransferases)IBA
04/2004
1Endothelin-1 (Endothelin 1)IBA
03/2004
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
03/2004
1Choline (Choline Chloride)IBA
08/2003

Therapy/Procedure

1Drug Therapy (Chemotherapy)
03/2006